4 peer-reviewed sources, DOI-verifiedUpdated Oct 1, 2026How we verify
Search “supplements for anxiety” and you’ll find confident claims about magnesium, L-theanine and ashwagandha. Here’s what the research we could verify actually shows. Short version: some early results are interesting, none of it is strong, and safety matters.
Before you start any supplement, talk to a doctor or pharmacist — especially if you take prescription medicines, are pregnant or breastfeeding, or have a long-term health condition. Supplements are not a substitute for professional care.
Magnesium C · Preliminary
A systematic review of 18 studies found the evidence was suggestive of a benefit on subjective anxiety in groups already vulnerable to anxiety, such as mildly anxious people or those with premenstrual symptoms. But the authors rated the quality of the evidence as poor, and magnesium had no effect on postpartum anxiety.
Evidence was suggestive of a benefit of magnesium on subjective anxiety in anxiety-vulnerable samples, but the quality of the evidence was poor.
Safety note: magnesium interacts with some medicines and isn’t suitable for everyone, for example people with kidney disease.
L-theanine C · Preliminary
L-theanine is an amino acid found in tea. In a small randomized, placebo-controlled crossover trial with 30 healthy adults, four weeks of 200 mg a day reduced stress-related symptom scores and improved sleep-quality scores compared with placebo.
Four weeks of 200 mg/day L-theanine reduced stress-related symptom scores and improved sleep-quality scores versus placebo in healthy adults.
Thirty people is a small sample, so this needs to be repeated in larger studies.
Ashwagandha C · Preliminary
In a 60-day randomized, double-blind trial with 60 stressed but healthy adults, a standardized ashwagandha extract was linked to lower anxiety ratings and lower morning cortisol than placebo.
In stressed healthy adults, 60 days of a standardized ashwagandha extract reduced anxiety ratings and morning cortisol versus placebo.
Safety note: ashwagandha isn’t recommended in pregnancy, there have been rare reports of liver injury, and it may interact with thyroid and other medicines.
What has stronger evidence?
If you want the best return on your effort, habits with stronger research include aerobic exercise, slow resonance breathing, relaxation training and mindfulness courses. Compare them all in our Evidence Matrix.